Počet záznamů: 1  

Adenovirus-derived vectors for prostate cancer gene therapy

  1. 1.
    0351866 - UMCH-V 2011 US eng J - Článek v odborném periodiku
    de Vrij, J. - Willemsen, R. A. - Lindholm, L. - Hoeben, R. C. - Bangma, Ch. H. - Barber, Ch. - Behr, J.-P. - Briggs, S. - Carlisle, R. - Cheng, W.-S. - Dautzenberg, I. J. C. - de Ridder, C. - Dzojic, H. - Erbacher, P. - Essand, M. - Fisher, K. - Frazier, A. - Georgopoulos, L. J. - Jennings, I. - Kochanek, S. - Koppers-Lalic, D. - Kraaij, R. - Kreppel, F. - Magnusson, M. - Maitland, N. - Neuberg, P. - Nugent, R. - Ogris, M. - Remy, J.-S. - Scaife, M. - Schenk, E. - Schooten, E. - Seymour, L. - Slade, M. - Szyjanowicz, P. - Totterman, T. - Uil, T. G. - Ulbrich, Karel - van der Weel, L. - van Weerden, W. - Wagner, E. - Zuber, G.
    Adenovirus-derived vectors for prostate cancer gene therapy.
    Human Gene Therapy. Roč. 21, č. 7 (2010), s. 795-805. ISSN 1043-0342
    GRANT EU: European Commission(XE) 512087 - GIANT
    Klíčová slova: adenovirus * gene delivery * prostate cancer
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 4.829, rok: 2010

    Prostate cancer is a leading cause of death among men in Western countries. Whereas the survival rate approaches 100% for patients with localized cancer, the results of treatment in patients with metastasized prostate cancer at diagnosis are much less successful. The patients are usually presented with a variety of treatment options, but therapeutic interventions in prostate cancer are associated with frequent adverse side effects. Gene therapy and oncolytic virus therapy may constitute new strategies. Already a wide variety of preclinical studies has demonstrated the therapeutic potential of such approaches, with oncolytic prostate-specific adenoviruses as the most prominent vector. The state of the art and future prospects of gene therapy in prostate cancer are reviewed, with a focus on adenoviral vectors. We summarize advances in adenovirus technology for prostate cancer treatment and highlight areas where further developments are necessary.
    Trvalý link: http://hdl.handle.net/11104/0006179