The effect of low dose of vinclozolin on reproductive tract development in CD1 outbred mice

0349088 - BTÚ 2011 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Elzeinová, Fatima - Pěknicová, Jana - Nováková, Vendula - Buckiová, Daniela - Kubátová, Alena
The effect of low dose of vinclozolin on reproductive tract development in CD1 outbred mice.
Sborník - XIV. Symposium českých reprodukčních imunologů s mezinárodní účastí. Praha, 2008, s. 49-49.
[XIV. Symposium českých reprodukčních imunologů s mezinárodní účastí. Žďár nad Sázavou (CZ), 30.5.208-1.6.2008]
Grant CEP: GA MŠMT(CZ) 1M06011; GA MŠMT(CZ) 2B06151
Výzkumný záměr: CEZ:AV0Z50520701
Klíčová slova: vinclozolin * CD1 mouse * spermatozoa
Kód oboru RIV: DN - Vliv životního prostředí na zdraví

The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
Trvalý link: http://hdl.handle.net/11104/0189419