Experimental Endocrinology and Reproductive Biology

0339694 - FGÚ 2010 RIV US eng M - Část monografie knihy
Zemková, Hana - Balík, Aleš - Mazna, Petr
Melatonin Inhibition of Gonadotropin-releasing Hormone-induced Calcium Signaling and Hormone Secretion in neonatal Pituitary Gonadotrophs.
Experimental Endocrinology and Reproductive Biology. Enfield: Science Publishers, 2008 - (Haldar, C.; Singaravel, M.; Pandi-Perumal, S.), s. 59-82. ISBN 978-1-57808-518-7
Grant CEP: GA AV ČR(CZ) IAA500110702; GA ČR(CZ) GA305/07/0681
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: melatonin * gonadotropin-releasing hormone * anterior pituitary
Kód oboru RIV: ED - Fyziologie

Gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion in pituitary cells from neonatal animals is inhibited by melatonin, because these cells express functional MT1 subtype of melatonin receptors that are coupled to pertussis toxin-sensitive G proteins. Their activation oby melatonin leads also to a decrease in cAMP level, intracellular calcium and attenuated activity of protein kinase A
Trvalý link: http://hdl.handle.net/11104/0183140