Biological studies on chimeric dimers of oxytocin and the V.sub.2./sub.-antagonist, d(CH.sub.2./sub.).sub.5./sub.[D-Ile.sup.2./sup., Ile.sup.4./sup.]arginine vasopressin

0193810 - UOCHB-X 20000242 RIV US eng C - Konferenční příspěvek (zahraniční konf.)
Slaninová, Jiřina - Machová, Alena - Golser, R. - Chen, L. - Barany, G.
Biological studies on chimeric dimers of oxytocin and the V₂-antagonist, d(CH₂)₅[D-Ile², Ile⁴]arginine vasopressin.
Proceedings of the 16th American Peptide Symposium. Peptides for the New Millennium. Boston: Kluwer, 2000 - (Fields, G.; Tam, J.; Barany, G.), s. 643-644. ISBN 0-7923-6445-7.
[Peptides for the New Millennium. American Peptide Symposium /16./. Minneapolis (US), 26.06.1999-01.07.1999]
Grant CEP: GA AV ČR KSK2055603
Grant ostatní: NIH(US) GM 43552
Výzkumný záměr: CEZ:AV0Z4055905
Kód oboru RIV: CE - Biochemie

The synthesis and biological activity of antiparallel chimeric dimers combining into a sigle molecule the neurohypophyseal hormone oxytocin and the potent vasopressin V2-antagonist d(CH2)5[D-Ile2, Ile4] arginine vasopressin are described. Both chimeras lack pressor activity and have low uterotonic activities. Parallel chimera proved to be more effective in promoting sodium excretion than oxytocin.
Trvalý link: http://hdl.handle.net/11104/0089502