Počet záznamů: 1
Inhibition of HIV protease by monoclonal antibodies
- 1.0191521 - UMG-J 20033012 RIV US eng J - Článek v odborném periodiku
Řezáčová, Pavlína - Brynda, Jiří - Fábry, Milan - Hořejší, Magdalena - Štouračová, Renata - Lescar, J. - Riottot, M. M. - Sedláček, Juraj - Bentley, G. A.
Inhibition of HIV protease by monoclonal antibodies.
Journal of Molecular Recognition. 15(5), č. 15 (2002), s. 272-276. ISSN 0952-3499. E-ISSN 1099-1352
Grant CEP: GA AV ČR IAA5052502; GA ČR GV203/98/K023
Výzkumný záměr: CEZ:AV0Z5052915
Klíčová slova: monoclonal antibodies * HIV protease * crystal structure
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.838, rok: 2002
The protease of HIV plays a critical role in the maturation of the infectious particles of the virus. We have produced and characterized monoclonal antibodies inhibiting the HIV-1 protease with inhibition constants in nanomoler range. The structural analyses taken together with other functional data suggest the mechanisms of protease inhibition by these antibodies.
Trvalý link: http://hdl.handle.net/11104/0087266
Počet záznamů: 1