Synthetic macromolecular drug carriers: Biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors

0188482 - UMCH-V 20010260 RIV GB eng J - Článek v odborném periodiku
Kissel, M. - Peschke, P. - Šubr, Vladimír - Ulbrich, Karel - Schuhmacher, J. - Debus, J. - Friedrich, E.
Synthetic macromolecular drug carriers: Biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.
P D A Journal of Pharmaceutical Science and Technology. Roč. 55, č. 3 (2001), s. 191-201. ISSN 1079-7440
Grant CEP: GA ČR GV307/96/K226; GA AV ČR KSK2055603
Výzkumný záměr: CEZ:AV0Z4050913
Klíčová slova: EPR effect * gamma camera imaging * tumor uptake
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 0.534, rok: 2001

The fate and total body distribution of soluble synthetic copolymers of N-(2-hydroxypropyl)methacrylamide, differing in molecular weight from 23.4 kD to 60.1 kD, were monitored scintigraphically after radiolabeling with 131 I during a seven day time window in Copenhagen rats bearing Dunning prostate carcinomas. Obtained data are of fundamental interest for ongoing studies on the pharmacokinetics of synthetic polymers, especially when these molecules are conjugated with targeting moieties and therapeutic or diagnostic agents.
Trvalý link: http://hdl.handle.net/11104/0084421