0173617 - UEM-P 20023072 RIV US eng J - Článek v odborném periodiku
Havlíčková, Michaela - Prezeau, L. - Duthey, B. - Bettler, B. - Pin, J. P. - Blahoš, Jaroslav
The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric Gamma-Aminobutyrate B Receptor.
Molecular Pharmacology. Roč. 62, č. 2 (2002), s. 343-350. ISSN 0026-895X. E-ISSN 1521-0111
Grant CEP: GA ČR GA301/00/0654; GA MZd NL6114; GA MZd NF6704
Výzkumný záměr: CEZ:AV0Z5008914
Klíčová slova: GABA * Gamma-aminobutyrate * GPCR
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 5.480, rok: 2002

Our data revealed the following new information on the G-protein coupling of the heteromeric GABAB receptor: 1) the i2 loop of GB2 within the GB2 HD is required for the heteromeric GABAB receptor to couple to G-proteins, whereas the i2 loop of GB1 is not; 2) the presence of the i2 loop of GB2 within the GB1 HD is not sufficient to allow coupling of GB1; 3) the GB2 HD activates the Gqi9 protein whether it is associated with the GB2 or GB1 ECD; 4) in the combination with two GB2 HDs, each is able to couple to G-proteins.
Trvalý link: http://hdl.handle.net/11104/0070647