Počet záznamů: 1  

Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs

  1. 1.
    0173343 - UEM-P 20003066 RIV US eng J - Článek v odborném periodiku
    Melčák, Ivo - Cermanová, Štěpánka - Jirsová, Kateřina - Koberna, Karel - Malínský, Jan - Raška, Ivan
    Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs.
    Molecular Biology of the Cell. Roč. 11, - (2000), s. 497-510. ISSN 1059-1524
    Grant CEP: GA ČR GA302/99/0587; GA ČR GA304/00/1481; GA MŠk VS96129
    Grant ostatní:Wellcome grant(XX) 049949/Z/97/Z/JMW/JPS/CG
    Výzkumný záměr: CEZ:AV0Z5039906
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 8.482, rok: 2000

    In the present study, the spatial organization of intron - containing pre-mRNAs of Epstein - Barr virus (EBV) genes relative to location of splicing factors is investigated. The intranuclear position of transcriptionally active EBV genes, as well as oof nascent transcripts, is found to be randonwith respect to the speckled accumulations of splicing factors (SC35 domains) in Namalwa cells, arguing against the concept of the locus - specific organization of mRNA genes with respect to the speckles.
    Trvalý link: http://hdl.handle.net/11104/0070377