0172267 - UEB-Q 20023052 RIV DE eng J - Článek v odborném periodiku
Maloň, M. - Trávníček, Z. - Maryško, Miroslav - Marek, J. - Doležal, Karel - Rolčík, Jakub - Strnad, Miroslav
Synthesis, characterization and antitumour activity of copper(II) 6-(4-chlorobenzylamino)purine complexes. X-ray structure of 6-(4-chloro-benzylamino)purinium perchlorate.
Transition Metal Chemistry. Roč. 27, č. 6 (2002), s. 580-586. ISSN 0340-4285. E-ISSN 1572-901X
Grant CEP: GA ČR GA522/01/0275; GA MŠMT OC 844.10; GA ČR GA301/02/0475
Výzkumný záměr: CEZ:AV0Z5038910
Klíčová slova: Copper complexes * human malignant melanoma * purinium perchlorate
Kód oboru RIV: CE - Biochemie
Impakt faktor: 0.949, rok: 2002

Copper(II) complexes with 6-(4-chlorobenzylamino)purine (HL) have been prepared and characterized by elemental analysis, electronic, i.r., ES + mass and 13C-n.m.r. spectra, and by magnetic and conductivity data. Based on these physical methods, mainly the temperature dependence of magnetic susceptibility data, we conclude that the complexes are: [Cu2-Cl)2(-HL)2Cl2] (1) and [CuCl3(H+L)2]Cl (2). They have been studied for their possible antitumour activity against human malignant melanoma G-361, human osteogenic sarcoma HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma MCF7 cells in vitro. The IC50 values were determined by calcein AM assay. The molecular structure of 6-(4-chlorobenzylamino)purinium perchlorate, i.e. a protonated form of the free HL ligand, has been determined by a single crystal X-ray analysis.
Trvalý link: http://hdl.handle.net/11104/0069306