Počet záznamů: 1  

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

  1. 1.
    0043297 - UEM-P 2007 RIV US eng J - Článek v odborném periodiku
    Bertaso, F. - Lill, Y. - Airas, J.M. - Espeut, J. - Blahoš, Jaroslav - Bockaert, J. - Fagni, L. - Betz, H. - Far, O.E.
    MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels.
    [MacMARCKS interaguje s metabotropním glutamátovým receptorem 7 and moduluje G protein-zprostředkovanou konstitutivní inhibici kalciových kanálů.]
    Journal of Neurochemistry. Roč. 99, - (2006), s. 288-298. ISSN 0022-3042
    Grant CEP: GA ČR GA204/05/0920
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: calmodulin * metabotropic glutamate receptor * calcium channel
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.260, rok: 2006

    We identified macrophage myristoylated alanine-rich c-kinase substrate (MacMARCKS) as a binding protein to metabotropic glutamate receptor 7 (mGluR7). Binding of MacMARCKS to mGluR7 was antagonized by Ca2+/calmodulin. In neurons, cotransfection of MacMARCKS with mGluR7, but not mGluR7 mutants unable to bind MacMARCKS, reduced the G-protein-mediated tonic inhibition of VSCCs in the absence of mGluR7 agonist.

    Identifikovali jsme partnera metabotropního glutamátového receptoru 7, kterým je macrophage myristoylated alanine-rich c-kinase substrate (MacMARCKS). Tato interakce je antagonisovaná Ca2+/calmodulinem. V neuronech kotransfekce MacMARCKS a mGluR7 redukuje bez agonisty tonickou inhibici VSCC kanálu.
    Trvalý link: http://hdl.handle.net/11104/0136321