Počet záznamů: 1  

The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC

  1. 1.
    0022207 - MBU-M 2006 RIV SIGLE US eng J - Článek v odborném periodiku
    Procházková, Kateřina - Osička, Radim - Linhartová, Irena - Halada, Petr - Šulc, Miroslav - Šebo, Peter
    The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC.
    [Lipoprotein FrpD z vnější membrány Neisseria meningitidis váže RTXC protein FrpD.]
    Journal of Biological Chemistry. Roč. 280, č. 5 (2005), s. 3251-3258. ISSN 0021-9258
    Grant CEP: GA ČR GA310/02/1448
    Grant ostatní:Howard Hughes Medical Institute International Research Scholarship Award 55000334
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: neisseria meningitidis * FrpD * FrpC
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 5.854, rok: 2005

    At conditions of low iron availability, Neisseria meningitidis produces a family of FrpC-like, type I-secreted RTX proteins of unknown role in meningococcal lifestyle. It is shown here that iron starvation also induces production of FrpD, the other protein expressed from a gene located immediately upstream of the frpC gene in a predicted iron-regulated frpDC operon. We found that FrpD is highly conserved in a set of meningococcal strains representative of all serogroups and does not exhibit any similarity to known sequences of other organisms. Subcellular localization and [3H]palmitic acid labeling in Escherichia coli revealed that FrpD is synthesized with a type II signal peptide for export across the cytoplasmic membrane and is, upon processing to a lipoprotein, sorted to the outer bacterial membrane.

    V podmínkách limitace růstu meningokoků koncentrací volného železa exprimují tyto protein FrpD. V práci je ukázáno, že se jedná o lipoprotein, který je lokalizovánm do vnější bakteriální membrány a váže sekretovaný RTX protein FrpC z vysokou afinitou
    Trvalý link: http://hdl.handle.net/11104/0110990