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SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry
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SYSNO ASEP 0462216 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry Tvůrce(i) Brůhová Michalčíková, R. (CZ)
Dryahina, Kseniya (UFCH-W) RID, ORCID
Španěl, Patrik (UFCH-W) RID, ORCIDZdroj.dok. International Journal of Mass Spectrometry. - : Elsevier - ISSN 1387-3806
Roč. 396, FEB 2016 (2016), s. 35-41Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Selected ion flow tube mass spectrometry ; Ion molecule reactions ; Three body association Vědní obor RIV CF - Fyzikální chemie a teoretická chemie CEP GA13-28882S GA ČR - Grantová agentura ČR Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000370307500005 EID SCOPUS 84956740983 DOI 10.1016/j.ijms.2015.12.007 Anotace Several compounds were previously identified as being present in modified concentrations in the breath of patients with inflammatory bowel diseases, IBD: 2-methylpentane, 1,3,5-triazine, trans-2-octene, cis-2-nonen-1-ol, 2′-methylacetophenone, 1-heptene and 2-hexanone. A selected ion flow tube, SIFT, study has thus been carried out of the reactions of H3O+, NO+ and O2+radical dot with these volatile organic compounds. The rate constants and product ion branching ratios of the primary reactions including three body association rate constants, describing the rate of hydration, were obtained. The results of this study allow accurate SIFT-MS quantification of concentrations of these compounds in exhaled breath of IBD patients with the ultimate aim of establishing their use as non-invasive biomarkers of the disease activity.
Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2017
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