Počet záznamů: 1

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

  1. 1.
    0370173 - FGU-C 2012 RIV GB eng J - Článek v odborném periodiku
    Smolková, Katarína - Plecitá-Hlavatá, Lydie - Bellance, N. - Benard, G. - Rossignol, R. - Ježek, Petr
    Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells.
    International Journal of Biochemistry and Cell Biology. Roč. 43, č. 7 (2011), s. 950-968 ISSN 1357-2725
    Grant CEP: GA MZd NR7778; GA MŠk(CZ) ME09029; GA AV ČR(CZ) IAA500110701
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: metabolic changes * mitochondria * carcinogenesis
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.634, rok: 2011

    In this review authors posit following hypothesis: Independently of whether malignant tumors are initiated by a fundamental reprogramming of gene expression or seeded by stem cells, waves of gene expression that promote metabolic changes occur during carcinogenesis, beginning with oncogene-mediated changes, followed by hypoxia-induced factor (HIF)-mediated gene expression, both resulting in the highly glycolytic Warburg phenotype and suppression of mitochondrial biogenesis
    Trvalý link: http://hdl.handle.net/11104/0204050