Počet záznamů: 1

Polyglutamate copolymers as a tissue-engineering platform: polymer scaffold modification through aminolysis of poly(.gamma.-benzyl-L-glutamate-co-2,2,2-.gamma.-trichlorethyl-L-glutamate)

  1. 1.
    0369730 - UMCH-V 2012 RIV GB eng J - Článek v odborném periodiku
    Svobodová, Jana - Rypáček, František
    Polyglutamate copolymers as a tissue-engineering platform: polymer scaffold modification through aminolysis of poly(.gamma.-benzyl-L-glutamate-co-2,2,2-.gamma.-trichlorethyl-L-glutamate).
    European Polymer Journal. Roč. 48, č. 1 (2012), s. 183-190 ISSN 0014-3057
    Grant CEP: GA AV ČR KJB400500904; GA ČR GAP108/11/1857; GA MŠk 1M0538
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: poly(.gamma.-benzyl-L-glutamate) * 2,2,2-.gamma.-trichlorethyl-L-glutamate * fibres
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 2.562, rok: 2012

    Homopolymers of γ-benzyl-L-glutamate (BLG) and its copolymers with more reactive 2,2,2-γ-trichlorethyl-L-glutamate (TCEG) were synthesized by ROP of respective N-carboxyanhydrides (NCA). The feasibility of functional modification of polyglutamate films and fibres through aminolysis of glutamate side chains with 2-aminoethanol or with a 2-aminoethanol/1,6-diaminohexane mixture was studied. The progress and extent of polymer side chain modification were analyzed by following methods: (a) the conversion of aminolysis of BLG units alone was determined from the amount of released benzyl alcohol extracted into hexane and followed by HPLC analysis, (b) the conversion of aminolysis of TCEG units was calculated from elemental analysis, (c) the depth and extend of films surface modification was evaluated ATR IR measurements and (d) the amount of free amino groups, created by aminolysis with 1,6-diaminohexane, was quantified by reaction with 2,4,6-trinitrobenzenesulfonic acid.
    Trvalý link: http://hdl.handle.net/11104/0006754