Počet záznamů: 1

Physiotherapy as an immunoactive therapy? A pilot study

  1. 1.
    0369644 - UIVT-O 2013 RIV SE eng J - Článek v odborném periodiku
    Řasová, K. - Doležil, D. - Kalistová, H. - Kučera, P. - Juzová, O. - Zimová, D. - Medová, E. - Jandová, D. - Tintěra, J. - Ibrahim, I. - Zvára, Karel - Bičíková, M. - Martinková, Patrícia
    Physiotherapy as an immunoactive therapy? A pilot study.
    Neuroendocrinology Letters. Roč. 33, č. 1 (2012), s. 67-75 ISSN 0172-780X
    Grant CEP: GA MŠk(CZ) 1M06014
    Výzkumný záměr: CEZ:AV0Z10300504
    Klíčová slova: multiple sclerosis * physiotherapy * facilitation * humoral and cellular immunity * immunomodulation * dehydroepiandrosterone
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 0.932, rok: 2012

    The aim of this study was to confirm the immunoregulatory and anti-inflammatory changes in the immunologic profile after two months of the facilitation physiotherapy in patients with multiple sclerosis (MS); and to determine whether the changes in the immunologic profile correlate with the changes in dehydroepiandrosterone, the brain microstructure and clinical functions. A group of 12 MS patients was examined twice: at the beginning and 2 months later after the patients had undergone the facilitation therapy. Standardized tests evaluating chosen clinical functions (balance, righting, equilibrium and protective reactions, tremor, dysdiadochokinesis, dysmetry, fine hand function and walking), immune parameters (parameters of the humoral and cellular immunity), dehydroepiandrosterone and diffusion tensor imaging (the fractional anisotropy, mean diffusivity) were measured. The patients underwent the facilitation physiotherapy in two sessions lasting two hours each week for two months. All clinical and diffusion tensor imaging parameters significantly improved following the therapy. Without the correction for multiple comparisons, there were significant changes in the IgG, IgG1 subclasses, in the numbers of Neutrophils and Lymphocytes, the T cells (CD3+) absolute number, the T cytotoxic subpopulation (CD3+CD8+) absolute number, B cells (CD19+) and the Natural killer cells. In addition, there was a significant correlation between the changes in the clinical functions and the changes in IgG1, and between the changes in the mean diffusivity and the changes in CD3+CD8+ absolute. The changes in the immune parameters and the mentioned correlations were not significant in view of the number of comparisons and thus necessitate further validation. No changes in the dehydroepiandrosterone concentration after the therapy were confirmed. The study suggests new possibilities of physiotherapy to influence the psycho–neuro–endocrine– immune response in MS patients.
    Trvalý link: http://hdl.handle.net/11104/0203660