Počet záznamů: 1

Alarmin HMGB1 is released in the small intestine of gnotobiotic piglets infected with enteric pathogens and its level in plasma reflects severity of sepsis

  1. 1.
    0369569 - MBU-M 2012 RIV US eng J - Článek v odborném periodiku
    Šplíchalová, Alla - Šplíchal, Igor - Chmelařová, Petra - Trebichavský, Ilja
    Alarmin HMGB1 is released in the small intestine of gnotobiotic piglets infected with enteric pathogens and its level in plasma reflects severity of sepsis.
    Journal of Clinical Immunology. Roč. 31, č. 3 (2011), s. 488-497 ISSN 0271-9142
    Grant CEP: GA MŠk ME 915
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: HMGB1 * enteric infection * cytokines
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.077, rok: 2011

    High mobility group box 1 (HMGB1) is essential for correct DNA folding and transcription and can be released from damaged cells or secreted by stimulated cells. One-week-old germ-free piglets were orally infected/colonized with enteric bacterial pathogens (Salmonella Typhimurium or Escherichia coli O55) or with probiotic bacteria (E. coli Nissle 1917) for 24 h. The local and systemic expression of HMGB1 is a suitable marker of severity of sepsis in the gnotobiotic piglet infection model
    Trvalý link: http://hdl.handle.net/11104/0203600