Počet záznamů: 1

The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?

  1. 1.
    0369486 - BTO-N 2012 RIV US eng J - Článek v odborném periodiku
    Zobalová, Renata - Prokopová, Kateřina - Stantic, M. - Stapelberg, M. - Dong, L.-F. - Ralph, S.J. - Akporiaye, E. - Neužil, Jiří
    The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?.
    Antioxidants & Redox Signaling. Roč. 15, č. 12 (2011), s. 2989-3002 ISSN 1523-0864
    Grant CEP: GA ČR(CZ) GA204/08/0811; GA ČR(CZ) GA305/07/1008
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: Cancer stem-like cells * protein CD133 * apoptosis
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 8.456, rok: 2011

    Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality.
    Trvalý link: http://hdl.handle.net/11104/0203538