Počet záznamů: 1
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex
0369361 - BU-J 2012 RIV GB eng J - Článek v odborném periodiku
Nosál´ová, G. - Capek, P. - Flešková, D. - Jureček, L´. - Hindák, F. - Lukavský, Jaromír - Cepák, Vladislav - Ray, B. - Breierová, E. - Turjan, J.
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex.
International Journal of Biological Macromolecules. Roč. 49, č. 4 (2011), 1046-1050 ISSN 0141-8130
Grant CEP: GA MŠk 1M0571
Výzkumný záměr: CEZ:AV0Z60050516
Klíčová slova: Rhodella griesea * proteoglykan * cough
Kód oboru RIV: EF - Botanika
Impakt faktor: 2.453, rok: 2011
An algal extracellular biopolymer (over 8.5 × 105 Da) composed of carbohydrates (52%) and protein (13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (63%), galactose (12%), glucuronic acid (11–12%), glucose (5%), rhamnose (4%), fucose (3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.
Trvalý link: http://hdl.handle.net/11104/0203444