Počet záznamů: 1

(Carboxydiamine)Pt(II) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects

  1. 1.
    0368769 - BFU-R 2012 RIV GB eng J - Článek v odborném periodiku
    Zoldakova, M. - Biersack, B. - Kostrhunová, Hana - Ahmad, A. - Padhye, S. - Sarkar, F.H. - Schobert, R. - Brabec, Viktor
    (Carboxydiamine)Pt(II) complexes of a combretastatin A-4 analogous chalcone: the influence of the diamine ligand on DNA binding and anticancer effects.
    MedChemComm. Roč. 2, č. 6 (2011), s. 493-499 ISSN 2040-2503
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: platinum * DNA binding * anticancer effects
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.800, rok: 2011

    The combretastatin A-4 analogue m-hydroxychalcone was esterified with a (1-carboxyethane-2,3-diamine)dichloridoplatinum(II) fragment to give complex which was more active against various cancer cell lines (IC50<1 mM) than its analogue bearing a 6-aminomethylnicotinate ligand.
    Trvalý link: http://hdl.handle.net/11104/0203018