Počet záznamů: 1

Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord

  1. 1.
    0368699 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Perrin, F. E. - Gerber, Y. N. - Teigell, M. - Lonjon, N. - Boniface, G. - Bauchet, L. - Rodríguez Arellano, Jose Julio - Hugnot, J. P. - Privat, A. M.
    Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord.
    Cell Death & Disease. Roč. 2, - (2011), e218 ISSN 2041-4889
    Grant CEP: GA ČR GA309/09/1696; GA ČR(CZ) GAP304/11/0184
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: genito-urinary tract * locomotion * nociceptive pathway
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 5.333, rok: 2011

    Here, we have performed a preliminary mapping of serotonergic processes and serotonin-lA (5-HT(1A)) receptors in thoracic and lumbar segments of the human spinal cord. 5-HT profiles in human spinal cord are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at lumbar level. 5-HT(1A) receptors are present in the same area, but are more densely expressed at lumbar level. These findings pave the way for local specific therapies involving cellular and/or pharmacological tools targeting the serotonergic system.
    Trvalý link: http://hdl.handle.net/11104/0202973