Počet záznamů: 1

THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE

  1. 1.
    0368591 - UEB-Q 2012 RIV JP eng J - Článek v odborném periodiku
    Jedinák, L. - Kryštof, Vladimír - Cankař, Petr
    THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE.
    Heterocycles. Roč. 88, č. 2 (2011), s. 371-383 ISSN 0385-5414
    Grant CEP: GA ČR GA301/08/1649
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Knoevenagel Condensation * Olefin Reduction * CDK * Hydrazine Cycloaddition * Pyrazole-3,5-diamine
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 0.999, rok: 2011

    The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were directly transformed by the reduction of the electron deficient C=C bond to benzylmalononitriles 5. Subsequent cycloaddition of hydrazine with 5 afforded the desired pyrazoles 2. Due to the high similarity with 4-arylazo-1H-pyrazole-3,5-diamines, the biological activities of the 4-benzyl-1H-pyrazole-3,5-diamines 2 were evaluated while focusing on the inhibition of cyclin-dependent kinases (CDKs), but no significant results were obtained.
    Trvalý link: http://hdl.handle.net/11104/0202890