Počet záznamů: 1

Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

  1. 1.
    0368248 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Forostyak, Serhiy - Jendelová, Pavla - Kapcalová, Miroslava - Arboleda Toro, David - Syková, Eva
    Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis.
    Cytotherapy. Roč. 13, č. 9 (2011), s. 1036-1046 ISSN 1465-3249
    Grant CEP: GA MŠk(CZ) LC554; GA ČR(CZ) GAP304/11/0189
    Grant ostatní: GA MŠk(CZ) 1M0538; GA ČR(CZ) GD309/08/H079
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: motor neurons * neurodegenerative diseases * stem cells
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 3.627, rok: 2011

    In current study transgenic rats overexpressing mutant human SOD1 were used as a model of fALS. We have found that grafting of MSC into symptomatic rats had a significant effect on motor activity and grip strength and longer lifespan if compared with the control group of animals. Transplanted cells survived and migrated in the spinal cord until the end stage of the disease without any side effects. Combined delivery of BM-derived MSC, therefore, could be an attractive approach for bench-to bedside studies in the treatment of ALS.
    Trvalý link: http://hdl.handle.net/11104/0202644