Počet záznamů: 1

Neurogenesis in Alzheimer´s disease

  1. 1.
    0367673 - UEM-P 2012 RIV GB eng J - Článek v odborném periodiku
    Rodríguez Arellano, Jose Julio - Verkhratsky, Alexei
    Neurogenesis in Alzheimer´s disease.
    Journal of Anatomy. Roč. 219, č. 1 (2011), s. 78-89 ISSN 0021-8782
    Grant CEP: GA ČR GA309/09/1696; GA ČR(CZ) GAP304/11/0184; GA ČR GA309/08/1381; GA ČR GA305/08/1384
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: Alzheimer's disease * hippocampus * neurodegeneration
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.370, rok: 2011

    Here, we overviewed the relations between adult neurogenesis and Alzheimer’s disease, and try to analyse the controversies in the field. We also summarised recent data obtained in the triple transgenic model of AD that show time- and region-specific impairment of neurogenesis, which may account for the early changes in synaptic plasticity and cognitive impairments that develop prior to gross neurodegenerative alterations and that could underlie new rescue therapies.
    Trvalý link: http://hdl.handle.net/11104/0202265