Počet záznamů: 1

IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus

  1. 1.
    0367385 - BC-A 2012 RIV AU eng J - Článek v odborném periodiku
    Franta, Zdeněk - Sojka, Daniel - Frantová, Helena - Dvořák, Jan - Horn, Martin - Srba, Jindřich - Talacko, Pavel - Mareš, Michael - Schneider, E. - Craik, C. S. - McKerrow, J. H. - Caffrey, C. R. - Kopáček, Petr
    IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.
    International Journal for Parasitology. Roč. 41, č. 12 (2011), 1253-1262 ISSN 0020-7519
    Grant CEP: GA AV ČR IAA600960910; GA ČR(CZ) GAP207/10/2183; GA ČR GPP502/11/P682; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518; CEZ:AV0Z40550506
    Klíčová slova: tick gut * hemoglobin digestion * cathepsin L
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 3.393, rok: 2011

    Blood digestion in the tick gut is based on a multienzyme network comprising acidic peptidases of cysteine and aspartic class. In this work, we provided the detailed biochemical and functional characterization of the cathepsin L named IrCL1 which is involved in the early stage of hemoglobin digestion. Our results suggest that IrCL1 is a promising candidate for development a potential anti-tick vaccine. The article impact was emphasized by the cover page image of the IJP issue.
    Trvalý link: http://hdl.handle.net/11104/0202091