Počet záznamů: 1

Nanomechanics of magnetically driven cellular endocytosis

  1. 1.
    0367265 - FZU-D 2012 RIV US eng J - Článek v odborném periodiku
    Zablotskyy, Vitaliy A. - Lunov, O. - Dejneka, Alexandr - Jastrabík, Lubomír - Polyakova, T. - Syrovets, T. - Simmet, T.
    Nanomechanics of magnetically driven cellular endocytosis.
    Applied Physics Letters. Roč. 99, č. 18 (2011), 183701/1-183701/3 ISSN 0003-6951
    Grant CEP: GA AV ČR KAN301370701; GA MŠk(CZ) 1M06002
    Výzkumný záměr: CEZ:AV0Z10100522
    Klíčová slova: magnetically controled endocytosis * cell membranes * iron oxide nanoparticles
    Kód oboru RIV: BM - Fyzika pevných látek a magnetismus
    Impakt faktor: 3.844, rok: 2011

    Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment.
    Trvalý link: http://hdl.handle.net/11104/0202008