Počet záznamů: 1

Functionalization of osmium arene anticancer complexes with (poly)arginine: Effect on cellular uptake, internalization, and cytotoxicity

  1. 1.
    0367048 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    van Rijt, S.H. - Kostrhunová, Hana - Brabec, Viktor - Sadler, P.J.
    Functionalization of osmium arene anticancer complexes with (poly)arginine: Effect on cellular uptake, internalization, and cytotoxicity.
    Bioconjugate Chemistry. Roč. 22, č. 2 (2011), s. 218-226 ISSN 1043-1802
    Grant CEP: GA ČR(CZ) GAP301/10/0598
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: osmium * arginine * cellular accumulation
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.930, rok: 2011

    Os complexes conjugated to Arg5 and Arg8 increase Os uptake into A2780 human ovarian cancer cells by 2x and 10x, respectively. A 15-fold increase in binding of Os to DNA was observed for Arg8. The complexes exhibited an ability to precipitate DNA.
    Trvalý link: http://hdl.handle.net/11104/0201838