Počet záznamů: 1

Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors

  1. 1.
    0366522 - MBU-M 2012 RIV NL eng J - Článek v odborném periodiku
    Drozdová, Anna - Bojarová, Pavla - Křenek, Karel - Weignerová, Lenka - Hensen, B. - Elling, L. - Christensen, H. - Jensen, H.H. - Pelantová, Helena - Kuzma, Marek - Bezouška, Karel - Krupová, Monika - Adámek, David - Slámová, Kristýna - Křen, Vladimír
    Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors.
    Carbohydrate Research. Roč. 346, č. 12 (2011), s. 1599-1609 ISSN 0008-6215
    Grant CEP: GA ČR GP203/09/P024; GA ČR GD305/09/H008; GA ČR GA303/09/0477
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: beta-N-Acetylhexosaminidase * alactosyltransferase * Enzymatic glycosylation
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.332, rok: 2011

    This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied
    Trvalý link: http://hdl.handle.net/11104/0201491