Počet záznamů: 1

Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells

  1. 1.
    0366512 - BFU-R 2012 RIV IE eng J - Článek v odborném periodiku
    Umannová, Lenka - Machala, M. - Topinka, Jan - Schmuczerová, Jana - Krčmář, P. - Neča, J. - Šujanová, Klára - Kozubík, Alois - Vondráček, Jan
    Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.
    Toxicology Letters. Roč. 206, č. 2 (2011), s. 121-129 ISSN 0378-4274
    Grant CEP: GA ČR(CZ) GAP503/11/1227
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
    Klíčová slova: DNA adducts * proinflammatory cytokines * COX-2
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.230, rok: 2011

    In the present study, we report data showing that a proinflammatory cytokine and environmentally-relevant polycyclic aromatic hydrocarbon interact to potentiate both DNA damage and the inflammatory response in alveolar epithelial type II cells, which may occur through coordinated upregulation of p38 MAP kinase activity.
    Trvalý link: http://hdl.handle.net/11104/0201482