Počet záznamů: 1

Novel polymeric nanoparticles assembled by metal ion addition

  1. 1.
    0366448 - UMCH-V 2012 RIV DE eng J - Článek v odborném periodiku
    Škodová, Michaela - Hrubý, Martin - Filippov, Sergey K. - Karlsson, G. - Macková, Hana - Špírková, Milena - Kaňková, Dana - Steinhart, Miloš - Štěpánek, Petr - Ulbrich, Karel
    Novel polymeric nanoparticles assembled by metal ion addition.
    Macromolecular Chemistry and Physics. Roč. 212, č. 21 (2011), s. 2339-2348 ISSN 1022-1352
    Grant CEP: GA ČR GPP207/10/P054; GA ČR GA202/09/2078; GA MŠk 1M0505
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: drug delivery systems * hydroxamic acid * nanoparticles
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 2.361, rok: 2011

    Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions, the self-assembly is slow (within minutes) with low efficiency. With Fe3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity.
    Trvalý link: http://hdl.handle.net/11104/0201437