Počet záznamů: 1

Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces

  1. 1.
    0366346 - MBU-M 2012 RIV GB eng J - Článek v odborném periodiku
    Řezanka, Tomáš - Siřišťová, L. - Schreiberová, O. - Řezanka, M. - Masák, J. - Melzoch, K. - Sigler, Karel
    Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces.
    Environmental Microbiology. Roč. 13, č. 6 (2011), s. 1577-1589 ISSN 1462-2912
    Grant CEP: GA MŠk 2B08062
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: PERFORMANCE LIQUID-CHROMATOGRAPHY * AVERMECTIN BIOSYNTHESIS * SELECTIVE PRODUCTION
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 5.843, rok: 2011

    A biosynthetic pathway using pivalic acid as a starter unit was found in three bacterial species, Alicyclobacillus acidoterrestris, Rhodococcus erythropolis and Streptomyces avermitilis. When deuterium-labelled pivalic acid was added to A. acidoterrestris and R. erythropolis nutrient media it was incorporated into fatty acids to give rise to tert-butyl fatty acids (t-FAs). In addition, in R. erythropolis, pivalic acid was transformed into two starter units, i.e. isobutyric and 2-methylbutyric acid, which served as precursors of corresponding iso-even FAs and anteiso-FAs. In S. avermitilis the biosynthesis also yielded all three branched FAs; apart from this pathway, both pivalic and 2-methylbutyric acids were incorporated into the antibiotic avermectin
    Trvalý link: http://hdl.handle.net/11104/0201387