Počet záznamů: 1

Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand

  1. 1.
    0365895 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Kisová, Anna - Zerzánková, Lenka - Habtemariam, A. - Sadler, P.J. - Brabec, Viktor - Kašpárková, Jana
    Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand.
    MOLECULAR PHARMACEUTICS. Roč. 8, č. 3 (2011), s. 949-957 ISSN 1543-8384
    Grant CEP: GA MŠk(CZ) LC06030; GA ČR(CZ) GD301/09/H004
    Grant ostatní: GA ČR(CZ) GPP303/11/P047; GA MŠk(CZ) OC09018
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: ruthenium * antitumor * cellular response
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.782, rok: 2011

    The new antitumor monofunctional Ru(II)-arene complex [eta6-arene)Ru(II)(en)Cl]+, where en = [1,2-diaminoethane and the arene is para-terphenyl] inhibits growth of the cancer cells through induction of apoptotic cell death and G0/G1 cell cycle arrest. Further investigations have shown that the ruthenium complex induces apoptosis by regulating the expression of Bc1-2 family proteins.
    Trvalý link: http://hdl.handle.net/11104/0006613