Počet záznamů: 1

Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis

  1. 1.
    0365891 - BFU-R 2012 RIV US eng J - Článek v odborném periodiku
    Cang, X. - Šponer, Jiří - Cheatham III, T.E.
    Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis.
    Journal of the American Chemical Society. Roč. 133, č. 36 (2011), s. 14270-14279 ISSN 0002-7863
    Grant CEP: GA ČR(CZ) GA203/09/1476; GA MŠk(CZ) LC06030; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GAP208/11/1822
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: molecular dynamics * DNA * quadruplex
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 9.907, rok: 2011

    The lengths of G-tracts and their connecting loop sequences determine G-quadruplex folding and stability. Here, single-loop G-quadruplexes were investigated using explicit solvent molecular dynamics (MD) simulations to characterize the effect of loop length, loop sequence, and G-tract length on the folding topologies and stability of G-quadruplexes.
    Trvalý link: http://hdl.handle.net/11104/0201030