Počet záznamů: 1

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

  1. 1.
    0365728 - FGU-C 2012 RIV GB eng J - Článek v odborném periodiku
    McDermott-Roe, Ch. - Ye, J. - Ahmed, R. - Sun, X. M. - Serafín, A. - Ware, J. - Bottolo, L. - Muckett, P. - Caňas, X. - Zhang, J. - Rowe, G. C. - Buchan, R. - Lu, H. - Braithwaite, A. - Mancini, M. - Hauton, D. - Martí, R. - García-Arumí, E. - Hubner, N. - Jacob, H. - Serikawa, T. - Zídek, Václav - Papoušek, František - Kolář, František - Cardona, M. - Ruiz-Meana, M. - García-Dorado, D. - Comella, J. X. - Felkin, L. E. - Barton, P. J. R. - Arany, Z. - Pravenec, Michal - Petretto, E. - Sanchis, D. - Cook, S.A.
    Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
    Nature. Roč. 478, č. 7367 (2011), s. 114-118 ISSN 0028-0836
    Grant CEP: GA MŠk(CZ) 1M0520; GA ČR(CZ) GA301/08/0166
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: left ventricular hypertrophy * endonuclease G * mitochondrial dysfunction
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 36.280, rok: 2011

    Left ventricular mass (LVM) is a highly heritable trait and an independent risk factor for all-cause mortality. We identified mutation in endonuclease G (Endog) that is associated with increased LVM and impaired cardiac function. Our study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy
    Trvalý link: http://hdl.handle.net/11104/0200901