Počet záznamů: 1

GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis

  1. 1.
    0365270 - UEB-Q 2012 RIV GB eng J - Článek v odborném periodiku
    Bohmdorfer, G. - Schleiffer, A. - Brunmeir, R. - Ferscha, S. - Nizhynska, V. - Kozák, Jaroslav - Angelis, Karel - Kreil, D. P. - Schweizer, D.
    GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis.
    Plant Journal. Roč. 67, č. 3 (2011), s. 420-433 ISSN 0960-7412
    Grant CEP: GA MŠk 1M0505; GA MŠk(CZ) LC06004
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: structural maintenance of chromosomes * DNA repair * somatic homologous recombination
    Kód oboru RIV: EI - Biotechnologie a bionika
    Impakt faktor: 6.160, rok: 2011

    DNA double-strand breaks (DSBs) pose one of the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joining and/or homologous recombination. Many components of these processes are still unknown in Arabidopsis thaliana. In this work, we characterized gamma-irradiation and mitomycin C induced 1 (GMI1), a member of the SMC-hinge domain-containing protein family. RT-PCR analysis and promoter-GUS fusion studies showed that gamma-irradiation, the radio-mimetic drug bleocin, and the DNA cross-linking agent mitomycin C strongly enhance GMI1 expression particularly in meristematic tissues. The induction of GMI1 by gamma-irradiation depends on the signalling kinase Ataxia telangiectasia-mutated (ATM) but not on ATM and Rad3-related (ATR).
    Trvalý link: http://hdl.handle.net/11104/0200553
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