Počet záznamů: 1

Parallels in understanding the endocrine control of lifespan with the firebug Pyrrhocoris apterus and the fruit fly Drosophila melanogaster

  1. 1.
    0365249 - BC-A 2012 RIV GB eng M - Část monografie knihy
    Hodková, Magdalena - Tatar, M.
    Parallels in understanding the endocrine control of lifespan with the firebug Pyrrhocoris apterus and the fruit fly Drosophila melanogaster.
    Mechanisms of Life History Evolution. The Genetics and Physiology of Life History Traits and Trade-offs. Oxford: Oxford University Press, 2011 - (Flatt, T.; Heyland, A.), s. 171-179. ISBN 978-0-19-956877-2
    Grant CEP: GA ČR GA206/05/2222; GA ČR GAP502/10/1612
    Výzkumný záměr: CEZ:AV0Z50070508
    Klíčová slova: Pyrrhocoris apterus * Drosophila melanogaster * endocrine control
    Kód oboru RIV: ED - Fyziologie

    In many organisms reproduction is negatively correlated with lifespan. Juvenile hormone (JH) is currently considered to play a key role in the modulation of this trade-off in insects but the way it does so remains unknown. Complementary approaches in two models, the firebug P. apterus and the genetic workhorse Drosophila melanogaster, help to uncover these mechanisms. Hypothetically, JH might accelerate aging via its well-documented stimulating effect on reproduction. Combination of surgical interventions in Pyrrhocoris apterus demonstrated that egg production itself is not the mechanism by which JH accelerates aging. Yet, the genetic approach in D. melanogaster revealed that reproduction still seems to be central to the hormonal control of aging via hypothesized endocrine signals produced by the somatic gonad that are regulated by germ line stem cells.
    Trvalý link: http://hdl.handle.net/11104/0200534