Počet záznamů: 1

The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis

  1. 1.
    0365137 - UTIA-B 2012 RIV DK eng J - Článek v odborném periodiku
    Luchavová, M. - Zikán, V. - Michalská, D. - Raška, I. - Kuběna, Aleš Antonín - Štěpán, J. J.
    The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis.
    European Journal of Endocrinology. Roč. 164, č. 4 (2011), s. 643-648 ISSN 0804-4643
    Grant ostatní: GA MZd(CZ) NS10564
    Výzkumný záměr: CEZ:AV0Z10750506
    Klíčová slova: intact parathyroid-hormone * serum cortisol * diurnal rhythm * growth-hormone * in-vivo * resorption * osteoprotegerin * calcium * abnormalities * osteocalcin
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 3.423, rok: 2011
    http://library.utia.cas.cz/separaty/2011/E/kubena-the effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis.pdf http://library.utia.cas.cz/separaty/2011/E/kubena-the effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis.pdf

    We hypothesized that with the administration of teriparatide (TPTD) treatment at different times, we would be able to modify the physiological circadian rhythm of bone turnover. The concentration of serum C-terminal telopeptide of collagen type I (beta CTX), serum N-terminal propeptide of procollagen type I (P1NP), serum ionized calcium (iCa), and plasma PTH were measured every 3 h over a 24 h period in 14 postmenopausal osteoporotic women (aged 72.4 +/- 9.3 years) treated with 20 mu g TPTD for long term, given at different times of the day. General linear model-repeated measurements (GLM RM) were performed to analyze the circadian rhythms as well as intergroup comparisons.
    Trvalý link: http://hdl.handle.net/11104/0200452