Počet záznamů: 1

Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor

  1. 1.
    0365067 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Petrenko, N. - Khafizov, K. - Tvrdoňová, Vendula - Skorinkin, A. - Giniatullin, R.
    Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor.
    Biochemistry. Roč. 50, č. 39 (2011), s. 8427-8436 ISSN 0006-2960
    Grant ostatní: Univerzita Karlova(CZ) 3446/2011
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: P2X3 * purinergic * ATP * ATP-binding pocket * receptor
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 3.422, rok: 2011

    In this work, by exploring in silico the functional role for the left flipper located in the ectodomain region, we identified within this loop a candidate residue S275, which could contribute to the closure of the agonist-binding pocket. Testing of the S275 mutants using the patch-clamp technice revealed a crucial role for S275 in agonist binding and receptor desensitization
    Trvalý link: http://hdl.handle.net/11104/0200403