Počet záznamů: 1

Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus

  1. 1.
    0364792 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Zemková, Hana - Stojilkovič, S.S. - Klein, D. C.
    Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus.
    Endocrinology. Roč. 152, č. 10 (2011), s. 3842-3851 ISSN 0013-7227
    Grant CEP: GA ČR(CZ) GA305/07/0681
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: Ca2plus-activated Kplus channels * voltage-gated Ca2plus channels * electrical activity * pinealocyte
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.459, rok: 2011

    The pineal gland is a neuroendocrine transducer, which generates a nocturnal increase in melatonin production, reflecting stimulation by norepinephrine (NE). NE was found to act through alpha1B-adrenoreceptors in a concentration-dependent manner to produce a biphasic change in membrane potential: initial transient hyperpolarization is followed by stable depolarization. These observations indicate that both continuous elevation of intracellular Ca2plus and sustained depolarization are associated with and are likely to be required for activation of the pinealocyte
    Trvalý link: http://hdl.handle.net/11104/0200178