Počet záznamů: 1

Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study

  1. 1.
    0364530 - UOCHB-X 2012 RIV DE eng J - Článek v odborném periodiku
    Čeřovský, Václav - Slaninová, Jiřina - Fučík, Vladimír - Monincová, Lenka - Bednárová, Lucie - Maloň, Petr - Štokrová, Jitka
    Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study.
    Chembiochem. Roč. 12, č. 9 (2011), s. 1352-1361 ISSN 1439-4227
    Grant CEP: GA ČR GA203/08/0536
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: antimicrobial peptide * disulfide bridge * lucifensin * solid phase synthesis
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.944, rok: 2011

    Lucifensin, a novel insect defensin of medicinal maggots identified recently in our laboratory, is 40 amino acid residues and three intramolecular bridges peptide. Oxidative folding of linear lucifensin precursor prepared by solid phase peptide synthesis resulted in a peptide with a pattern of disulfide bridges identical to that of native lucifensin. Synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. The presence of disulfide bridges and the N-terminal part of its molecule for the structure and antimicrobial activity is essential.
    Trvalý link: http://hdl.handle.net/11104/0199997