Počet záznamů: 1

The inhibition of fat cell proliferation by fatty acids in dietary obese mice

  1. 1.
    0364484 - FGU-C 2012 RIV GB eng J - Článek v odborném periodiku
    Hensler, Michal - Bardová, Kristina - Macek Jílková, Zuzana - Wahli, W. - Meztger, D. - Chambon, P. - Kopecký, Jan - Flachs, Pavel
    The inhibition of fat cell proliferation by fatty acids in dietary obese mice.
    Lipids in Health and Disease. Roč. 10, - (2011), s. 128 ISSN 1476-511X
    Grant CEP: GA ČR(CZ) GAP301/11/0226; GA ČR(CZ) GD305/08/H037
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: DHA and EPA * fish oil * fat cell turnover
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 2.170, rok: 2011

    A model of inducible and reversible lipoatrophy (aP2-Cre-ERT2 PPARγL2/L2 mice) was used, in which the death of mature adipocytes could be achieved by a selective ablation of peroxisome proliferator-activated receptor γ in response to i.p. injection of tamoxifen. The results document that dietary LC n-3 PUFA could decrease adiposity in obese mice by a mechanism, which depends on counteraction of both, differentiation and proliferation of adipose cells. These results also support the notion that adiposity is closely linked to the control of fat cell turnover and that mechanisms could exist, which control fat cell proliferation independent of energy balance
    Trvalý link: http://hdl.handle.net/11104/0199960