Počet záznamů: 1
Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate
- 1.0364480 - FGÚ 2012 RIV NL eng J - Článek v odborném periodiku
Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristína - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., Ladislav - Valeš, Karel
Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate.
Neuropharmacology. Roč. 61, 1-2 (2011), s. 61-68. ISSN 0028-3908. E-ISSN 1873-7064
Grant CEP: GA MZd(CZ) NS10365; GA MZd(CZ) NR9180; GA ČR(CZ) GA309/07/0271; GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/09/0286; GA MŠMT(CZ) 1M0517; GA MŠMT(CZ) LC554
Grant ostatní: EC(XE) LSMH-CT-2007-037765
Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z40550506
Klíčová slova: neuroactive steroid * NMDA * neuroprotectivity
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.814, rok: 2011
The results show that 3alfa5betaPregnanolone glutamate, use-dependent NMDA antagonist, is able to cross the blood brain barrier, does not induce psychotomimetic symptoms (such as hyperlocomotion and sensorimotor gating deficit) and reduced an excitotoxic damage of brain tissue and subsequent behavioural impairment in rats
Trvalý link: http://hdl.handle.net/11104/0199958
Počet záznamů: 1