Počet záznamů: 1

Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate

  1. 1.
    0364480 - FGU-C 2012 RIV NL eng J - Článek v odborném periodiku
    Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristina - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., Ladislav - Valeš, Karel
    Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate.
    Neuropharmacology. Roč. 61, 1-2 (2011), s. 61-68 ISSN 0028-3908
    Grant CEP: GA MZd(CZ) NS10365; GA MZd(CZ) NR9180; GA ČR(CZ) GA309/07/0271; GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/09/0286; GA MŠk(CZ) 1M0517; GA MŠk(CZ) LC554
    Grant ostatní: EC(XE) LSMH-CT-2007-037765
    Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z40550506
    Klíčová slova: neuroactive steroid * NMDA * neuroprotectivity
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 4.814, rok: 2011

    The results show that 3alfa5betaPregnanolone glutamate, use-dependent NMDA antagonist, is able to cross the blood brain barrier, does not induce psychotomimetic symptoms (such as hyperlocomotion and sensorimotor gating deficit) and reduced an excitotoxic damage of brain tissue and subsequent behavioural impairment in rats
    Trvalý link: http://hdl.handle.net/11104/0199958