Počet záznamů: 1

Altered neural and vascular mechanisms in hypertension

  1. 1.
    0364294 - FGU-C 2012 RIV CZ eng J - Článek v odborném periodiku
    Pintérová, Mária - Kuneš, Jaroslav - Zicha, Josef
    Altered neural and vascular mechanisms in hypertension.
    Physiological Research. Roč. 60, č. 3 (2011), s. 381-402 ISSN 0862-8408
    Grant CEP: GA ČR(CZ) GA305/09/0336
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: adrenoceptors * G proteins * L-type voltage-dependent calcium channels * potassium channels * RhoA/Rho kinase * genetic hypertension
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 1.555, rok: 2011

    This review is focused on two major antagonistic players in the regulation of blood pressure, i.e. sympathetic nervous system (by stimulation of adrenoceptors coupled to stimulatory and inhibitory G proteins) and nitric oxide (by cGMP signaling pathway), elicit their actions via the control of calcium influx through L-VDCC. However, L-type calcium current can also be regulated by the changes in membrane potential elicited by the activation of potassium channels, the impaired function of which was detected in hypertensive animals. The dominant role of enhanced calcium influx in the pathogenesis of high blood pressure of genetically hypertensive animals is confirmed not only by therapeutic efficacy of calcium antagonists but especially by the absence of hypertension in animals in which L-type calcium current was diminished by pertussis toxin-induced inactivation of inhibitory G proteins
    Trvalý link: http://hdl.handle.net/11104/0199815