Počet záznamů: 1

Telomore maintenance on organisms without telomerase

  1. 1.
    0364291 - BC-A 2012 RIV HR eng M - Část monografie knihy
    Mason, J. M. - Reddy, H. M. - Čapková Frydrychová, Radmila
    Telomore maintenance on organisms without telomerase.
    DNA Replication-Current Advances. Rijeka: InTech, 2011 - (Seligmann, H.), s. 323-346. ISBN 978-953-307-593-8
    Grant ostatní:EU program FP7-REGPOT-2008-1(CZ) MOBITAG project 229518
    Výzkumný záměr: CEZ:AV0Z50070508
    Klíčová slova: telomere
    Kód oboru RIV: EB - Genetika a molekulární biologie

    Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a few times in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.
    Trvalý link: http://hdl.handle.net/11104/0199812