Počet záznamů: 1

pH-triggered block copolymer micelles based on a pH-responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate]) inner core and a PEO (poly(ethylene oxide)) outer shell as a potential tool for the cancer therapy

  1. 1.
    0364286 - UMCH-V 2012 RIV GB eng J - Článek v odborném periodiku
    Giacomelli, F. C. - Štěpánek, Petr - Giacomelli, C. - Schmidt, V. - Jäger, Eliezer - Jäger, Alessandro - Ulbrich, Karel
    pH-triggered block copolymer micelles based on a pH-responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate]) inner core and a PEO (poly(ethylene oxide)) outer shell as a potential tool for the cancer therapy.
    Soft Matter. Roč. 7, č. 19 (2011), s. 9316-9325 ISSN 1744-683X
    Grant CEP: GA ČR GAP208/10/1600
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: copolymer micelles * light scattering * cancer therapy
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 4.390, rok: 2011

    The potential of a novel pH-triggered block copolymer as a promising drug delivery platform for the cancer therapy has been explored. The block copolymer poly(ethylene oxide)-b-poly(glycerol monomethacrylate)-b-poly[2-(diisopropylamino)ethyl methacrylate] self-assembled into highly regular spherical micelles whose structure was characterized in detail by light scattering, small angle X-ray scattering, fluorescence spectroscopy and transmission electron microscopy. The micellar size (42 nm) and micellar molecular weight were found to be in the range to avoid renal clearance providing a long blood circulation time. The pH-responsive core could be loaded with the poorly water-soluble anti-cancer drug paclitaxel (PTX) with encapsulation efficiency 70%. The release experiments evidenced that the micellar dissociation might be triggered at the slightly acid tumoral extracellular environments.
    Trvalý link: http://hdl.handle.net/11104/0199808