Počet záznamů: 1

Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides

  1. 1.
    0364260 - UOCHB-X 2012 RIV GB eng J - Článek v odborném periodiku
    Nečas, D. - Hidasová, D. - Hocek, Michal - Kotora, Martin
    Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides.
    Organic & Biomolecular Chemistry. Roč. 9, č. 17 (2011), s. 5934-5937 ISSN 1477-0520
    Grant CEP: GA MŠk 1M0508; GA AV ČR IAA400550902
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: efficient synthesis * indole derivatives * aromatic stacking * DNA * cyclization
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.696, rok: 2011

    A simple two-step method for the selective preparation of anomerically pure 1 alpha- and 1 beta-(indol-2-yl)deoxyribose derivatives was developed. The synthesis was based on the Sonogashira reaction of 1 alpha- and 1 beta-ethynyldeoxyribose and 2-haloanilines followed by a Pd-complex catalyzed cyclization to the corresponding indolyldeoxyribosides.
    Trvalý link: http://hdl.handle.net/11104/0199786