Počet záznamů: 1

Synthesis of pregnane 3-carboxylic acids via Pd-catalyzed alkoxycarbonylation and their effect on NMDA receptor activity

  1. 1.
    0363595 - UOCHB-X 2012 RIV CZ eng J - Článek v odborném periodiku
    Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Borovská, Jiřina - Vyklický ml., Ladislav
    Synthesis of pregnane 3-carboxylic acids via Pd-catalyzed alkoxycarbonylation and their effect on NMDA receptor activity.
    Collection of Czechoslovak Chemical Communications. Roč. 76, č. 9 (2011), s. 1141-1161 ISSN 0010-0765
    Grant CEP: GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/07/0271
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50110509
    Klíčová slova: neurosteroids * carboxylic acid * alkoxycarbonylation * steroids * NMDA receptor activity
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.283, rok: 2011

    We have prepared 20-oxo-5alpha- and 20-oxo-5beta-pregnane-3-carboxylic acids by palladium catalyzed alkoxycarbonylation using triflate and nonaflate as the leaving groups in this substitution reaction. The activity of the synthesized compounds was studied in cultured rat hippocampal neurons under voltage-clamp conditions. The 5beta-carboxylic acid derivatives were found to diminish NMDA-induced responses, whereas the 5alpha-derivative potentiated the response.
    Trvalý link: http://hdl.handle.net/11104/0199354