Počet záznamů: 1

6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs

  1. 1.
    0363423 - UOCHB-X 2012 RIV NL eng J - Článek v odborném periodiku
    de Jersey, J. - Holý, Antonín - Hocková, Dana - Naesens, L. - Keough, D. T. - Guddat, L. W.
    6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs.
    Current Topics in Medicinal Chemistry. Roč. 11, č. 16 (2011), s. 2085-2102 ISSN 1568-0266
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: Malaria * acyclic nucleoside phosphonates * hypoxanthine * guanine phosphoribosyl transferase
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 4.174, rok: 2011

    Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates. The focus of this review is on the identification and characterization of inhibitors of the key enzyme in this pathway - 6-oxopurine phosphoribosyltransferase. The acyclic nucleoside phosphonates (ANPs) appear to be excellent candidates that can be selective compared to the human enzyme.
    Trvalý link: http://hdl.handle.net/11104/0006532