Počet záznamů: 1

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

  1. 1.
    0363152 - UOCHB-X 2012 RIV FR eng J - Článek v odborném periodiku
    Jansa, Petr - Baszczyňski, Ondřej - Dračínský, Martin - Votruba, Ivan - Zídek, Zdeněk - Bahador, G. - Stepan, G. - Cihlar, T. - Mackman, R. - Holý, Antonín - Janeba, Zlatko
    A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
    European Journal of Medicinal Chemistry. Roč. 46, č. 9 (2011), s. 3748-3754 ISSN 0223-5234
    Grant CEP: GA MV VG20102015046
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50390703
    Klíčová slova: prodrugs * phosphonodiamides * bis-amidates * acyclic nucleoside phosphonates * GS-9219
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.346, rok: 2011

    A novel and efficient method for the one-pot synthesis of diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates, starting from free phosphonic acids or phosphonate diesters is reported. The methodology has been applied to the synthesis of the potent anticancer agent GS-9219, and symmetrical bis-amidates of other biologically active phosphonic acids.
    Trvalý link: http://hdl.handle.net/11104/0199212