Počet záznamů: 1

Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

  1. 1.
    0363004 - MBU-M 2012 RIV GB eng J - Článek v odborném periodiku
    Kverka, Miloslav - Zákostelská, Zuzana - Klimešová, Klára - Sokol, Dan - Hudcovic, Tomáš - Hrnčíř, Tomáš - Rossmann, Pavel - Mrázek, Jakub - Kopečný, Jan - Verdu, E. - Tlaskalová-Hogenová, Helena
    Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition.
    Clinical and Experimental Immunology. Roč. 163, č. 2 (2011), s. 250-259 ISSN 0009-9104
    Grant CEP: GA AV ČR KJB500200904; GA AV ČR 1QS500200572; GA AV ČR IAA5020205; GA ČR GD310/08/H077; GA ČR GA303/08/0367; GA ČR GA305/08/0535
    Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z50450515
    Klíčová slova: animal models * cytokines/interleukins * DSS colitis
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.360, rok: 2011

    Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology
    Trvalý link: http://hdl.handle.net/11104/0199146