Počet záznamů: 1

Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level

  1. 1.
    0361510 - UOCHB-X 2012 RIV PL eng J - Článek v odborném periodiku
    Nosáľ, R. - Perečko, T. - Jančinová, V. - Drábiková, K. - Harmatha, Juraj - Sviteková, K.
    Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level.
    Pharmacological Reports. Roč. 63, č. 3 (2011), s. 790-798 ISSN 1734-1140
    Grant CEP: GA ČR(CZ) GA203/07/1227
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: neutrophils * N-feruloylserotonin * extracellular and intracellular chemiluminescence
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.445, rok: 2011

    N-feruloylserotonin (N-f-5HT) isomers, isolated from seeds of Leuzea carthamoides, inhibited dose-dependent oxidative burst in human whole blood and isolated neutrophils in vitro, which were measured by luminol-and/or isoluminol-enhanced chemiluminescence. The results suggest that N-f-5HT isomers are an effective, naturally occurring substances with a potent pharmacological effect on the oxidative burst of human neutrophils.
    Trvalý link: http://hdl.handle.net/11104/0198810